Production of the staurosporine aglycon K-252c with a blocked mutant of the staurosporine producer strain Streptomyces longisporoflavus and by biotransformation of staurosporine with Streptomyces mediocidicus ATCC 13279.
作者信息
Goeke K, Hoehn P, Ghisalba O
机构信息
Ciba-Geigy AG, Pharmaceutical Division, Basel, Switzerland.
出版信息
J Antibiot (Tokyo). 1995 May;48(5):428-30. doi: 10.7164/antibiotics.48.428.
PMID:7797446
Abstract
摘要
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1
Production of the staurosporine aglycon K-252c with a blocked mutant of the staurosporine producer strain Streptomyces longisporoflavus and by biotransformation of staurosporine with Streptomyces mediocidicus ATCC 13279.利用星形孢菌素产生菌长孢黄链霉菌的一个阻断突变体以及通过用中等杀链霉菌ATCC 13279对星形孢菌素进行生物转化来生产星形孢菌素苷元K-252c。
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