Usdin T B, Gruber C, Bonner T I
Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892-4090, USA.
J Biol Chem. 1995 Jun 30;270(26):15455-8. doi: 10.1074/jbc.270.26.15455.
We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.
我们已鉴定出一种由甲状旁腺激素特异性激活的G蛋白偶联受体，我们将其称为PTH2受体。甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP，恶性肿瘤高钙血症因子）激活一种先前已鉴定出的PTH/PTHrP受体，该受体具有广泛的组织分布。PTH2受体在配体识别方面更具选择性，并且似乎具有更特定的组织分布。它由PTH激活而非PTHrP激活，在脑和胰腺中尤为丰富。
