Liu Y, Whitlock B B, Pultz J A, Wolfe S A
Department of Medical Microbiology and Immunology, Ohio State University College of Medicine, Columbus 43210-1239, USA.
J Neuroimmunol. 1995 Jun;59(1-2):143-54. doi: 10.1016/0165-5728(95)00032-w.
Neuroleptics, opiates, and cocaine are commonly prescribed for or abused by humans. Although primarily used for their actions at other receptors in brain, these compounds also act at sigma receptors. We have previously identified sigma-1 receptors on human peripheral blood leukocytes and rat spleen, and in the present study we demonstrate a correlation between the pharmacology of these receptors and the ability of drugs to suppress concanavalin A-induced splenocyte proliferation. These results support the hypothesis that sigma-1 receptors regulate functional activities of immune cells, and suggest that sigma agonists may cause changes in immune competence in vivo.
抗精神病药物、阿片类药物和可卡因通常被人类用于处方或滥用。尽管这些化合物主要作用于大脑中的其他受体，但它们也作用于σ受体。我们之前已在人外周血白细胞和大鼠脾脏中鉴定出σ-1受体，在本研究中，我们证明了这些受体的药理学与药物抑制伴刀豆球蛋白A诱导的脾细胞增殖能力之间的相关性。这些结果支持了σ-1受体调节免疫细胞功能活动的假说，并表明σ激动剂可能会在体内引起免疫能力的变化。
