Dinarello C A, Chusid M J, Fauci A S, Gallin J I, Dale D C, Wolff S M
Arthritis Rheum. 1976 May-Jun;19(3):618-22. doi: 10.1002/art.1780190315.
Patients with familial Mediterranean fever (FMF) who were part of a double-blind trial of daily colchicine as prophylaxis for their disease had leukocyte functions studied while receiving colchicine or placebo. Leukocytes taken from these patients while on prophylactic doses of colchicine produced normal quantities of leukocytic pyrogen, ingested bacteria normally, and migrated normally in chemotatic chambers. In addition these patients had normal numbers of circulating T and B lymphocytes as well as normal blastogenic reponses of their peripheral lymphocytes to mitogenic stimuli. The patients on colchicine, however, had significantly fewer neutrophils and monocytes accumulating at skin-window sites 24 hours after the initial abrasion. Because the early phase of the skin-window response was normal in these patients, the decreased late response may be related to a failure to amplify the initial inflammatory reaction. The reduced capacity to generate a normal inflammatory response may account for the failure of these patients to develop full attacks while taking colchicine.
作为每日服用秋水仙碱预防家族性地中海热（FMF）双盲试验一部分的患者，在接受秋水仙碱或安慰剂治疗时，对其白细胞功能进行了研究。在这些患者服用预防性剂量秋水仙碱期间采集的白细胞，产生正常数量的白细胞热原，正常摄取细菌，并在趋化室中正常迁移。此外，这些患者循环T淋巴细胞和B淋巴细胞数量正常，其外周淋巴细胞对有丝分裂刺激的增殖反应也正常。然而，服用秋水仙碱的患者在初次擦伤后24小时，皮肤窗口部位积聚的中性粒细胞和单核细胞明显减少。由于这些患者皮肤窗口反应的早期阶段正常，后期反应降低可能与无法放大初始炎症反应有关。产生正常炎症反应的能力降低，可能解释了这些患者在服用秋水仙碱时未能发生全面发作的原因。
