Thompson R J, Goldstein R F, Oehler J M, Gustafson K E, Catlett A T, Brazy J E
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina.
J Dev Behav Pediatr. 1994 Aug;15(4):232-8.
The relative contribution of biological and psychosocial risk factors to developmental outcome of 102 very low birth weight infants (< 1500 g) was delineated through 24 months corrected age. Biological risk, assessed by the Neurobiologic Risk Score (NBRS), accounted for significant amounts of variance in Bayley Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) at the 6-, 15-, and 24-month assessment points. Psychosocial risk, reflected in maternal appraisals of daily stress, accounted for a significant increment in cognitive outcome (MDI), over and above that accounted for by the NBRS, at each assessment point. Cognitive functioning at each assessment point differed as a function of biological risk and psychosocial risk status. The findings are discussed in terms of maternal stress as a marker of, and salient intervention target for, caregiving environments that can maximize or minimize the effects of biological vulnerability.
通过矫正年龄24个月，对102名极低出生体重婴儿（<1500克）的生物学和心理社会风险因素对发育结局的相对贡献进行了描述。通过神经生物学风险评分（NBRS）评估的生物学风险，在6个月、15个月和24个月评估点时，在贝利智力发育指数（MDI）和精神运动发育指数（PDI）中占显著比例的方差。母亲对日常压力的评估所反映的心理社会风险，在每个评估点时，在认知结局（MDI）中占比显著增加，超出了NBRS所解释的部分。每个评估点的认知功能因生物学风险和心理社会风险状况而异。根据母亲压力作为可最大化或最小化生物学脆弱性影响的照料环境的标志和显著干预目标，对研究结果进行了讨论。
