Stahr B J, Cooper P H, Caputo R V
Department of Pathology, Emory University, Atlanta, GA.
J Cutan Pathol. 1994 Aug;21(4):289-96. doi: 10.1111/j.1600-0560.1994.tb00702.x.
Neutrophilic eccrine hidradenitis (NEH) has been described in a variety of clinical settings but is most often seen in leukemic patients receiving chemotherapy. We have recently encountered 6 healthy individuals, of whom 5 were children, who developed NEH localized to the feet. The patients were from 9 to 21 years of age. The presenting complaint was rapid development of tenderness of the feet with varying degrees of morbidity. At clinical evaluation, tender, erythematous papules and nodules were confined to the feet, primarily the plantar surfaces. The major differential diagnoses were erythema nodosum and vasculitis. Laboratory studies were non-contributory. Histologically, the findings were generally similar to those of NEH with certain exceptions, most notably the absence of syringosquamous metaplasia and the presence, in most cases, of neutrophilic abscesses in eccrine coils. Inflammatory and degenerative changes involved primarily the eccrine duct (coiled and dermal), and tended to spare the secretory apparatus. Stains for microorganisms were negative. There were brief recurrences in some of the patients, but those followed over time have remained well. We suggest the term idiopathic plantar hidradenitis for this condition.
嗜中性小汗腺汗管炎(NEH)已在多种临床情况下被描述,但最常见于接受化疗的白血病患者。我们最近遇到了6名健康个体,其中5名是儿童,他们患上了局限于足部的NEH。这些患者年龄在9至21岁之间。主要症状是足部迅速出现压痛,并伴有不同程度的发病情况。临床评估时,压痛性红斑丘疹和结节局限于足部,主要在足底表面。主要的鉴别诊断是结节性红斑和血管炎。实验室检查无诊断价值。组织学上,其表现通常与NEH相似,但有某些例外,最显著的是没有汗腺鳞状化生,且在大多数情况下,汗腺螺旋管中有嗜中性脓肿。炎症和退行性改变主要累及汗腺导管(螺旋状和真皮内导管),而分泌装置往往未受影响。微生物染色为阴性。一些患者有短暂复发,但随着时间推移,他们都恢复良好。我们建议将这种情况称为特发性足底汗管炎。