规范化学换肤溶液配方以避免事故。三氯乙酸实际浓度波动很大。
Standardizing chemical peel solution formulations to avoid mishaps. Great fluctuations in actual concentrations of trichloroacetic acid.
作者信息
Bridenstine J B, Dolezal J F
机构信息
Department of Dermatology, University of Pittsburgh Medical Center, PA 15213.
出版信息
J Dermatol Surg Oncol. 1994 Dec;20(12):813-6. doi: 10.1111/j.1524-4725.1994.tb03710.x.
BACKGROUND
Chemical peeling using trichloroacetic acid (TCA) is a popular and long utilized procedure in dermatology and cosmetic surgery.
OBJECTIVE
To determine the actual concentration of TCA in four disparate methods of preparation of solutions, expressed in the standard pharmaceutical method of weight to volume (wt/vol).
METHODS
Method I was wt/vol, method II was weight to weight (wt/wt), method III was grams of TCA added to 100 cc water, and method IV was the usage of saturated TCA, and calling it 100%, then making appropriate dilutions. The amounts of TCA in each solution for methods II, III, and IV were converted, by calculation, to the wt/vol method.
RESULTS
The relative concentrations of TCA, ranked by the wt/vol pharmaceutical standard, showed that from strongest to weakest: method IV > method II > method I > method III.
CONCLUSIONS
Tremendous variations were found in the relative concentrations of TCA in these solutions. To avoid mishaps and complications, the wt/vol method should be used.
背景
使用三氯乙酸（TCA）进行化学剥脱术是皮肤科和整形手术中一种常用且长期应用的方法。
目的
以标准的药物重量/体积（wt/vol）方法，确定四种不同溶液配制方法中TCA的实际浓度。
方法
方法I为重量/体积法，方法II为重量/重量法（wt/wt），方法III为向100毫升水中加入TCA的克数，方法IV为使用饱和TCA并将其称为100%，然后进行适当稀释。通过计算将方法II、III和IV中每种溶液的TCA量转换为重量/体积法。
结果
按照重量/体积药物标准排列，TCA的相对浓度显示从最强到最弱依次为：方法IV > 方法II > 方法I > 方法III。
结论
这些溶液中TCA的相对浓度存在巨大差异。为避免事故和并发症，应使用重量/体积法。
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