Clark L E, Mellette J R
Department of Dermatology, University of Colorado Health Sciences Center, Denver.
J Dermatol Surg Oncol. 1994 Dec;20(12):842-4. doi: 10.1111/j.1524-4725.1994.tb03718.x.
Although the use of hyaluronidase as an adjunct to anesthesia is frequently described for plastic surgery and ophthalmologic procedures, its use in dermatologic surgery has not been well investigated.
In this report we review the advantages and disadvantages of using hyaluronidase in dermatologic procedures.
The effect of adding hyaluronidase to local anesthesia was evaluated in 72 operations performed over a 1-year period.
Although the duration of anesthesia is slightly decreased, the addition of hyaluronidase to local anesthesia offers the benefits of minimizing loss of surface contour and enhanced ease in undermining and dissection through subcutaneous tissue planes. The onset of anesthesia using hyaluronidase is immediate and the area of anesthesia appears increased over anesthesia without hyaluronidase.
We therefore recommend the adjunct of hyaluronidase to local anesthesia as a useful advancement in surgical technique.
尽管透明质酸酶作为麻醉辅助剂在整形手术和眼科手术中的应用经常被提及，但其在皮肤科手术中的应用尚未得到充分研究。
在本报告中，我们回顾了在皮肤科手术中使用透明质酸酶的优缺点。
在1年的时间里，对72例手术中添加透明质酸酶至局部麻醉的效果进行了评估。
尽管麻醉持续时间略有缩短，但在局部麻醉中添加透明质酸酶具有使表面轮廓损失最小化以及增强在皮下组织平面进行潜行分离和解剖的便利性等优点。使用透明质酸酶时麻醉起效迅速，且麻醉区域相较于未使用透明质酸酶的麻醉似乎有所增加。
因此，我们建议在局部麻醉中添加透明质酸酶，作为手术技术的一项有益进展。
