Schleimer R P, Bochner B S
Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224-6801.
J Allergy Clin Immunol. 1994 Dec;94(6 Pt 2):1202-13. doi: 10.1016/0091-6749(94)90333-6.
It is readily apparent that eosinophils are important targets of steroid effects. Disruption of the cytokine network by glucocorticoids can indirectly diminish eosinophil generation, survival, and function. In addition, glucocorticoids appear to have direct effects on the survival, and perhaps on the function, of these cells. Rapid advances in our knowledge of the biochemistry of signal transduction, as well as the interaction between cell surface receptors and RNA transcription machinery, will allow detailed analysis of the mechanisms by which the function and life cycle of eosinophils are influenced by glucocorticoids.
很明显，嗜酸性粒细胞是类固醇作用的重要靶点。糖皮质激素对细胞因子网络的破坏可间接减少嗜酸性粒细胞的生成、存活和功能。此外，糖皮质激素似乎对这些细胞的存活，甚至功能都有直接影响。我们在信号转导生物化学以及细胞表面受体与RNA转录机制之间相互作用方面的知识迅速进展，将使我们能够详细分析糖皮质激素影响嗜酸性粒细胞功能和生命周期的机制。
