Watanabe-Ohnishi R, Low D E, McGeer A, Stevens D L, Schlievert P M, Newton D, Schwartz B, Kreiswirth B, Kotb M
Department of Surgery, University of Tennessee.
J Infect Dis. 1995 Jan;171(1):74-84. doi: 10.1093/infdis/171.1.74.
The V beta repertoire of T cells of patients with gram-positive group A streptococcal (GAS) and non-GAS infections was analyzed to seek evidence for the role of superantigens in streptococcal toxic shock syndrome. No evidence of V beta overexpression but a consistent pattern of depletion of V beta 1, V beta 5.1, and V beta 12 was observed in patients with severe GAS infections. This pattern of V beta depletion was not observed in patients with nonsevere GAS infections or with severe non-GAS gram-positive infections. T cells from patients with severe GAS infections showed evidence of apoptosis; no apoptosis was found when there was no evidence of V beta depletion. There was no correlation with streptococcal M or T serotype or known spe genes. The depletion of specific V beta-bearing T cells in patients with severe GAS infections supports the role of a superantigen in these infections. The in vivo pattern of V beta specificity implicates a novel superantigen(s) in this disease.
分析了A组革兰氏阳性链球菌（GAS）感染和非GAS感染患者T细胞的Vβ谱，以寻找超抗原在链球菌中毒性休克综合征中作用的证据。在严重GAS感染患者中未观察到Vβ过表达的证据，但观察到Vβ1、Vβ5.1和Vβ12一致的耗竭模式。在非严重GAS感染患者或严重非GAS革兰氏阳性感染患者中未观察到这种Vβ耗竭模式。严重GAS感染患者的T细胞显示出凋亡的证据；当没有Vβ耗竭的证据时，未发现凋亡。这与链球菌M或T血清型或已知的spe基因无关。严重GAS感染患者中特定携带Vβ的T细胞的耗竭支持了超抗原在这些感染中的作用。Vβ特异性的体内模式表明该病存在一种新型超抗原。
