Nakagawa K, Yasumitsu T, Kotake Y, Ueshima S, Kazuo H, Tanemura M, Hirabayashi H, Ogawa T
Department of Surgery, Osaka Prefectural Habikino Hospital, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1994 Oct;42(10):1933-9.
Of 12 patients who underwent lung resections for lung cancer with idiopathic interstitial pneumonia (IIP), eight patients survived and four patients died due to acute exacerbation of IIP after the operation. The preoperative values for percent forced vital capacity, predicted postoperative percent vital capacity, percent one-second forced expiratory volume index and serum level of C-reactive protein were significantly different between the group of patients who survived and that of having died. Three days after the operation, the percentage of lymphocytes among leukocytes and serum level of lactate dehydrogenase in the two groups were both significantly different. These findings showed that the operative strategy for patients with lung cancer and IIP needs specifically careful consideration for operative procedure, and preoperative serum levels of C-reactive protein and postoperative lactate dehydrogenase and the percentage of lymphocytes in leukocytes would be useful in evaluation of the severity of IIP.
在12例因特发性间质性肺炎（IIP）接受肺癌肺切除术的患者中，8例存活，4例术后因IIP急性加重死亡。存活患者组和死亡患者组之间，术前用力肺活量百分比、预计术后肺活量百分比、一秒用力呼气量指数百分比及血清C反应蛋白水平的术前值存在显著差异。术后3天，两组白细胞中淋巴细胞百分比及血清乳酸脱氢酶水平均存在显著差异。这些结果表明，对于肺癌合并IIP患者的手术策略，在手术操作方面需要特别谨慎考虑，术前血清C反应蛋白水平、术后乳酸脱氢酶水平及白细胞中淋巴细胞百分比有助于评估IIP的严重程度。
