Borlongan C V, Cahill D W, Freeman T B, Sanberg P R
Department of Surgery, University of South Florida, College of Medicine.
J Fla Med Assoc. 1994 Oct;81(10):689-94.
Anatomical and behavioral characterizations of neural transplants, whether within (allograft) or across (xenograft) species, have provided evidence that the transplant survives, integrates with the host tissue, and may lead to functional recovery. Several animal models of neurodegenerative disorders demonstrate the feasibility of using neural transplantation as an alternative treatment for these human diseases. While more elaborate basic animal studies are needed, clinical trials have begun. Neural transplantation is currently used as an experimental treatment for Parkinson's disease and several investigators have suggested using the same treatment procedure for other neurodegenerative disorders, such as Huntington's and Alzheimer's disease.
神经移植的解剖学和行为学特征，无论是在同种（同种异体移植）还是跨物种（异种移植）之间，都已提供证据表明移植体能够存活，与宿主组织整合，并可能导致功能恢复。几种神经退行性疾病的动物模型证明了使用神经移植作为这些人类疾病替代治疗方法的可行性。虽然还需要更详尽的基础动物研究，但临床试验已经开始。神经移植目前被用作帕金森病的实验性治疗方法，并且一些研究人员已建议将相同的治疗程序用于其他神经退行性疾病，如亨廷顿舞蹈症和阿尔茨海默病。
