Yamamura K, Iwata H, Osada T, Yotsuyanagi T, Nabeshima T
Department of Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Jpn J Pharmacol. 1994 Jul;65(3):289-91. doi: 10.1254/jjp.65.289.
We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.
我们在群体大鼠软骨肉瘤模型中研究了载有多柔比星（ADR）的羟基磷灰石（HAP）微珠的抗肿瘤作用。当将一颗载有ADR的HAP微珠（ADR：0.8毫克/微珠）植入荷瘤大鼠的肿瘤中央部分时，载有ADR的HAP微珠显示出良好的治疗效果，使生存期延长（ILS）了90%。值得注意的是，未观察到白细胞减少和腹泻现象。这些结果表明，HAP给药提供了一种有趣且可能有效的方法。
