在群体大鼠软骨肉瘤模型中测定载有阿霉素的羟基磷灰石植入物的抗癌效果。

Anticancer effects of adriamycin-loaded hydroxyapatite implants determined in a Swarm rat chondrosarcoma model.

作者信息

Yamamura K, Iwata H, Osada T, Yotsuyanagi T, Nabeshima T

机构信息

Department of Hospital Pharmacy, Nagoya University School of Medicine, Japan.

出版信息

Jpn J Pharmacol. 1994 Jul;65(3):289-91. doi: 10.1254/jjp.65.289.

DOI:10.1254/jjp.65.289

PMID:7799530

Abstract

We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.

摘要

我们在群体大鼠软骨肉瘤模型中研究了载有多柔比星（ADR）的羟基磷灰石（HAP）微珠的抗肿瘤作用。当将一颗载有ADR的HAP微珠（ADR：0.8毫克/微珠）植入荷瘤大鼠的肿瘤中央部分时，载有ADR的HAP微珠显示出良好的治疗效果，使生存期延长（ILS）了90%。值得注意的是，未观察到白细胞减少和腹泻现象。这些结果表明，HAP给药提供了一种有趣且可能有效的方法。