Bloomfield S A, Jackson R D, Mysiw W J
Exercise Physiology Laboratory, School of HPER, Ohio State University, Columbus 43210.
Med Sci Sports Exerc. 1994 Oct;26(10):1213-9.
It is unknown whether the catecholamine (CAT) response to acute exercise and prolonged training in humans with spinal cord injury (SCI) is similar to that of neurologically intact man. Plasma samples were collected from seven subjects with chronic SCI (level of injury C5-T7) at rest and during voluntary arm-crank ergometry (ACE) before and after 6 months of training with functional electrical stimulation cycle ergometry (FES-CE). Similar plasma collections were made during one FES-CE exercise training session after 6 months of training. Norepinephrine (NE) and epinephrine (EPI) were measured by HPLC. After FES-CE training, resting NE decreased 37% (950 +/- 150 vs 1510 +/- 350 pmol.l-1 pretraining); resting EPI decreased 80% (54 +/- 10 vs 163 +/- 32 pmol.l-1 pretraining) (P < 0.05 by paired t-tests). No significant changes were observed in group means after training for the CAT response to submaximal ACE; however, five of seven subjects exhibited greater increments in plasma NE with ACE after FES-CE training. Acute FES-CE exercise elicited a 55-844% increase in NE, and a 35-350% increase in EPI above resting values with power outputs eliciting heart rates of 90-146 bpm. These data provide evidence for a systemic CAT response in subjects with SCI during acute FES-CE and reduced resting CAT following 6 months of training with FES-CE.
脊髓损伤（SCI）患者对急性运动和长期训练的儿茶酚胺（CAT）反应是否与神经功能正常的人相似尚不清楚。在7名慢性SCI患者（损伤水平为C5 - T7）休息时、进行功能性电刺激周期测力计（FES - CE）训练6个月前后的自愿手臂曲柄测力计（ACE）期间采集血浆样本。在训练6个月后的一次FES - CE运动训练期间进行类似的血浆采集。通过高效液相色谱法测量去甲肾上腺素（NE）和肾上腺素（EPI）。经过FES - CE训练后，静息NE下降了37%（训练前为950±150 vs 1510±350 pmol·l-1）；静息EPI下降了80%（训练前为54±10 vs 163±32 pmol·l-1）（配对t检验，P < 0.05）。训练后，对于次最大强度ACE的CAT反应，组均值未观察到显著变化；然而，7名受试者中有5名在FES - CE训练后进行ACE时血浆NE的增加幅度更大。急性FES - CE运动使NE增加了55 - 844%，EPI增加了35 - 350%，高于静息值，功率输出使心率达到90 - 146次/分钟。这些数据为SCI患者在急性FES - CE期间的全身性CAT反应以及FES - CE训练6个月后静息CAT降低提供了证据。
