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[传染性单核细胞增多症继发冷抗体型自身免疫性溶血性贫血伴血红蛋白尿]

[Autoimmune hemolytic anemia with cold antibodies and hemoglobinuria secondary to EBV infection].

作者信息

Cataldo F, Varrica D, Mele A, Oddo S, Varvarà M G, Albeggiani A

机构信息

Clinica Pediatrica R, Presidio Ospedaliero Aiuto Materno, Palermo.

出版信息

Minerva Pediatr. 1994 Sep;46(9):401-5.

PMID:7799888
Abstract

The infection caused by EBV can be followed by immunological complications. One of these is autoimmune hemolytic anemia that up to today has been observed during infective mononucleosis only a few times. The authors describe a patient with this rare complication of the EBV infection and discuss its main clinical, pathogenetic and laboratory aspects, with particular attention to the presence of hemoglobinuria and to the absence of anti-i-antibodies. The disease's evolution was spontaneously favorable. For this reason and for the possible risks secondary to transfusions and to other therapeutical interventions, the authors believe that in autoimmune hemolytic anemia a vigil wait is more opportune before beginning the therapy.

摘要

EBV感染可能会引发免疫并发症。其中之一是自身免疫性溶血性贫血,到目前为止,仅在传染性单核细胞增多症期间观察到过几次。作者描述了一名患有这种EBV感染罕见并发症的患者,并讨论了其主要的临床、发病机制和实验室方面,特别关注血红蛋白尿的存在以及抗i抗体的缺失。该疾病的病程自发好转。出于这个原因以及输血和其他治疗干预可能带来的风险,作者认为在自身免疫性溶血性贫血中,在开始治疗前进行密切观察更为合适。

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