Klaase J M, Kroon B B
Het Nederlands Kanker Instituut/Antoni van Leeuwenhoek Huis, afd. Chirurgie, Amsterdam.
Ned Tijdschr Geneeskd. 1994 Dec 10;138(50):2488-91.
Assessment of incidence and risk factors of late recurrence (after a disease-free interval of at least 10 years) following treatment for primary melanoma.
Retrospective study taking into account a total of 2579 melanoma patients admitted to the Netherlands Cancer Institute/Antoni van Leeuwenhoek Huis in the period 1956 to 1991; patients with ocular melanoma were excluded.
Twenty-three patients had a disease-free interval of at least 10 years (median 11 years; range: 10-21) after treatment for primary melanoma: 17 women and 6 men, with a median age of 43 years (20-62). This group predominantly consisted of women with a primary melanoma localised on the extremities. Most of them had melanomas of intermediate thickness (Breslow thickness: 1-2 mm). Patients with a first recurrence locoregionally (16) had a 5-year survival rate of over 50%; 6 of the 7 patients with a first relapse at distant sites died within a few months.
Melanoma patients who are discharged from follow-up after a disease-free interval of 10 years are advised to continue loco-regional self-examination.
评估原发性黑色素瘤治疗后晚期复发（无病间隔至少10年）的发生率及危险因素。
进行一项回顾性研究，纳入1956年至1991年期间荷兰癌症研究所/安东尼·范·列文虎克医院收治的总共2579例黑色素瘤患者；排除眼黑色素瘤患者。
23例患者在原发性黑色素瘤治疗后无病间隔至少10年（中位值11年；范围：10 - 21年）：17例女性和6例男性，中位年龄43岁（20 - 62岁）。该组主要为原发性黑色素瘤位于四肢的女性。他们大多数患有中等厚度的黑色素瘤（ Breslow厚度：1 - 2毫米）。首次复发为局部复发的患者（16例）5年生存率超过50%；7例首次远处复发的患者中有6例在几个月内死亡。
建议无病间隔10年后结束随访的黑色素瘤患者继续进行局部自我检查。
