Olbrich H M, Martin P
Psychiatrische Klinik und Poliklinik der Universität Freiburg.
Nervenarzt. 1994 Jul;65(7):482-5.
Three schizophrenic patients and one schizophreniform patient, all experiencing puerperal psychosis, required a drug-induced delactation (bromocriptine) simultaneously to neuroleptic treatment. Taking into account the pharmacodynamic effects, an exacerbation of symptoms following bromocriptine (a D-2 receptor agonist) and an impairment of delactation following neuroleptic treatment (bringing about the blockade of D-2 receptors) are to be expected. In three cases, we carried out a combined bromocriptine-haloperidol treatment and, in one case, a bromocriptine-clozapine treatment. The above mentioned complications were not observed in any of the cases. The problems which may result from using clozapine during the puerperal period are also discussed.
三名精神分裂症患者和一名精神分裂症样患者均患有产褥期精神病,在接受抗精神病药物治疗的同时,均需要药物性回奶(溴隐亭)。考虑到药效学作用,预计服用溴隐亭(一种D-2受体激动剂)后症状会加重,而抗精神病药物治疗(导致D-2受体阻断)后回奶会受到影响。我们对三例患者采用了溴隐亭-氟哌啶醇联合治疗,对一例患者采用了溴隐亭-氯氮平治疗。上述并发症在任何一例中均未观察到。文中还讨论了产褥期使用氯氮平可能产生的问题。