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[产褥期精神分裂症性精神病的药物治疗]

[Drug treatment of schizophrenic psychoses in puerperium].

作者信息

Olbrich H M, Martin P

机构信息

Psychiatrische Klinik und Poliklinik der Universität Freiburg.

出版信息

Nervenarzt. 1994 Jul;65(7):482-5.

PMID:7800093
Abstract

Three schizophrenic patients and one schizophreniform patient, all experiencing puerperal psychosis, required a drug-induced delactation (bromocriptine) simultaneously to neuroleptic treatment. Taking into account the pharmacodynamic effects, an exacerbation of symptoms following bromocriptine (a D-2 receptor agonist) and an impairment of delactation following neuroleptic treatment (bringing about the blockade of D-2 receptors) are to be expected. In three cases, we carried out a combined bromocriptine-haloperidol treatment and, in one case, a bromocriptine-clozapine treatment. The above mentioned complications were not observed in any of the cases. The problems which may result from using clozapine during the puerperal period are also discussed.

摘要

三名精神分裂症患者和一名精神分裂症样患者均患有产褥期精神病,在接受抗精神病药物治疗的同时,均需要药物性回奶(溴隐亭)。考虑到药效学作用,预计服用溴隐亭(一种D-2受体激动剂)后症状会加重,而抗精神病药物治疗(导致D-2受体阻断)后回奶会受到影响。我们对三例患者采用了溴隐亭-氟哌啶醇联合治疗,对一例患者采用了溴隐亭-氯氮平治疗。上述并发症在任何一例中均未观察到。文中还讨论了产褥期使用氯氮平可能产生的问题。

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