Abed W T
Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid.
Pharmacol Toxicol. 1994 Sep-Oct;75(3-4):162-5. doi: 10.1111/j.1600-0773.1994.tb00340.x.
The thresholds for pentylenetetrazol and lidocaine-induced clonic convulsions were significantly influenced by manipulation of brain biogenic amines. Pretreatment with inhibitors of monoamine synthesis, alpha-methyl-p-tyrosine and p-chlorophenylalanine, caused significant decreases in brain monoamine contents and pentylenetetrazol seizure threshold, while the threshold for lidocaine-induced convulsions was significantly increased by either treatment. Moreover, the inhibitor of dopamine-beta-hydroxylase, disulfiram, caused significant decrease in brain noradrenaline (NA) and significant increase in brain dopamine (DA) contents. The threshold for pentylenetetrazol-induced convulsions was decreased by treatment with disulfiram, while that of lidocaine was increased by the same treatment. Furthermore, treatment with L-dihydroxyphenylalanine (L-DOPA) caused significant increase in brain DA contents, while 5-hydroxytryptophan (5-HTP) treatment caused significant increase in brain 5-hydroxytryptamine (5-HT) contents, but the thresholds for lidocaine and pentylenetetrazol-induced convulsions were not influenced by either treatment. These results may suggest that the brain monoaminergic systems, different from their ability to inhibit control of pentylenetetrazol seizures, act to potentiate lidocaine-induced convulsions.
对脑内生物胺的调控显著影响了戊四氮和利多卡因诱发阵挛性惊厥的阈值。用单胺合成抑制剂α-甲基-对-酪氨酸和对氯苯丙氨酸预处理，可使脑内单胺含量和戊四氮惊厥阈值显著降低，而两种处理均可使利多卡因诱发惊厥的阈值显著升高。此外，多巴胺-β-羟化酶抑制剂双硫仑可使脑内去甲肾上腺素（NA）显著减少，脑内多巴胺（DA）含量显著增加。用双硫仑处理可降低戊四氮诱发惊厥的阈值，而对利多卡因诱发惊厥的阈值则有升高作用。此外，用L-二羟基苯丙氨酸（L-DOPA）处理可使脑内DA含量显著增加，而用5-羟色氨酸（5-HTP）处理可使脑内5-羟色胺（5-HT）含量显著增加，但两种处理均未影响利多卡因和戊四氮诱发惊厥的阈值。这些结果可能表明，脑内单胺能系统与它们抑制戊四氮惊厥控制的能力不同，其作用是增强利多卡因诱发的惊厥。
