Ribera R L, Valls J, González-Clemente J M, Vidal J, Manzanares J M, Esmatjes E
Servicio de Endocrinología, Hospital Clínic i Provincial, Barcelona.
Rev Clin Esp. 1994 Oct;194(10):901-5.
The usefulness of the quantitative measurement of vibration perception threshold (VPT) was assessed by a biothesiometer in the diagnosis of peripheral neuropathy in 36 patients with type I diabetes mellitus. The study included: a) clinical assessment (history and neurological examination); b) measurement of VPT at right metatarsus, right pretibial area and right metacarpus; c) electromiographical study (right peroneal, posterior tibial, right sural, right medial plantar); d) assessment of the autonomous nervous system (sympathetic and parasympathetic indexes); e) metabolic assessment (HbA1c at study and mean HbA1c in the previous year). The prevalence of peripheral neuropathy was 38%. VPT at metatarsal region in diabetic patients was higher than in controls (p < 0.05) and a positive correlation with evolution time of disease at metatarsal region (p < 0.05) and tibia (p < 0.05) was observed. Clinical symptoms and changes at examination correlated with VPT at metatarsus (p < 0.05) and tibia (p < 0.05). No relationship was observed between VPT and metabolic control. In conclusion, vibration threshold increases with evolution time in diabetes, but it was not influenced by metabolic control. Its measurement by a simple method, such as biothesiometer, could be useful in diagnosing peripheral neuropathy in clinically asymptomatic patients.
通过生物感觉测量仪评估振动觉阈值（VPT）定量测量在36例I型糖尿病患者周围神经病变诊断中的作用。该研究包括：a）临床评估（病史和神经学检查）；b）测量右跖骨、右胫前区和右掌骨的VPT；c）肌电图研究（右腓神经、胫后神经、右腓肠神经、右足底内侧神经）；d）自主神经系统评估（交感和副交感神经指数）；e）代谢评估（研究时的糖化血红蛋白A1c和前一年的平均糖化血红蛋白A1c）。周围神经病变的患病率为38%。糖尿病患者跖骨区域的VPT高于对照组（p<0.05），且观察到与跖骨区域（p<0.05）和胫骨（p<0.05）的疾病病程呈正相关。临床症状和检查中的变化与跖骨（p<0.05）和胫骨（p<0.05）的VPT相关。未观察到VPT与代谢控制之间的关系。总之，糖尿病患者的振动阈值随病程增加，但不受代谢控制的影响。通过生物感觉测量仪等简单方法测量VPT，可能有助于诊断临床无症状患者的周围神经病变。
