抗孕酮化合物RU486对经孕马血清促性腺激素/人绒毛膜促性腺激素处理的未成熟小鼠排卵的影响。

Effects of anti-progesterone compound RU486 on ovulation in immature mice treated with PMSG/hCG.

作者信息

Kanayama K, Sankai T, Nariai K, Endo T, Sakuma Y

机构信息

Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Nihon University, Kanagawa, Japan.

出版信息

Res Exp Med (Berl). 1994;194(4):217-20. doi: 10.1007/BF02576382.

DOI:10.1007/BF02576382

PMID:7800930

Abstract

The effects of RU486, a competitive antagonist of progesterone, on ovulation were studied in PMSG/hCG-treated immature mice. PMSG/hCG was administered to 3-week-old female mice to induce ovulation. A dose of 0.5 mg of RU486 was administered 3 h before hCG injection, simultaneously with hCG injection, or 3, 4.5, 6, 7.5 or 9 h after hCG administration. The lowest number of ovulated eggs was observed in the group given RU486 6 h after hCG injection. Although the mean number of ovulated eggs was only 4.4 in this group, it was increased to 25.7 by supplementary administration of 2.0 mg of progesterone. It was demonstrated that RU486 had inhibitory effects on ovulation, and the inhibition could be prevented by supplementary administration of progesterone.

摘要

在经孕马血清促性腺激素（PMSG）/人绒毛膜促性腺激素（hCG）处理的未成熟小鼠中，研究了孕酮竞争性拮抗剂米非司酮（RU486）对排卵的影响。给3周龄雌性小鼠注射PMSG/hCG以诱导排卵。在注射hCG前3小时、与hCG注射同时或在注射hCG后3、4.5、6、7.5或9小时给予0.5毫克RU486。在hCG注射后6小时给予RU486的组中观察到排卵卵数量最少。虽然该组排卵卵的平均数量仅为4.4，但通过补充2.0毫克孕酮可将其增加至25.7。结果表明，RU486对排卵有抑制作用，补充孕酮可防止这种抑制作用。