Hofmann-Lehmann R, Aubert A, Wolfensberger C, Cronier J, Lutz H
Departement für Innere Veterinärmedizin, Universität Zürich.
Schweiz Arch Tierheilkd. 1994;136(10):340-51.
A new recombinant FeLV vaccine was evaluated in 30 specified pathogen-free cats 10 months of age cats. The vaccine consisted of the non-glycosylated FeLV envelope protein p45, aluminium hydroxide and a saponin adjuvant. The cats (n = 18) were vaccinated twice intramuscularly, 3 weeks apart. All animals were challenged intraperitoneally with FeLV subgroup A, 18 weeks later. While 94% of the vaccinated cats showed no viraemia or were only transiently viraemic, 80% of the non-vaccinated animals became persistently viraemic within 2 to 3 weeks. In our hands the preventable fraction of the vaccine was 93%. In order to determine the effect of a pre-existing infection with feline immunodeficiency virus on the efficacy of vaccination, 50% of the cats were previously infected with FIV. The infected cats were protected to the same degree as the non-infected animals. With prolonged duration of FIV infection the probability increases, that the immune system of the cat will fail and clinical signs will appear. In order to observe a state of possible immunodeficiency, an accurate clinical examination of every cat prior to vaccination seems of major importance.
一种新型重组猫白血病病毒（FeLV）疫苗在30只10月龄的无特定病原体猫中进行了评估。该疫苗由非糖基化的FeLV包膜蛋白p45、氢氧化铝和一种皂苷佐剂组成。18只猫进行肌肉注射，间隔3周接种两次。18周后，所有动物经腹腔接种A亚群FeLV。接种疫苗的猫中94%未出现病毒血症或仅出现短暂病毒血症，而未接种疫苗的动物中80%在2至3周内出现持续性病毒血症。在我们的研究中，该疫苗的预防率为93%。为了确定猫免疫缺陷病毒（FIV）既往感染对疫苗效力的影响，50%的猫事先感染了FIV。感染FIV的猫与未感染的动物受到同等程度的保护。随着FIV感染时间延长，猫免疫系统功能衰竭并出现临床症状的可能性增加。为了观察可能的免疫缺陷状态，在接种疫苗前对每只猫进行准确的临床检查似乎至关重要。
