Fach W A, Kostanecka T, Kober G
Klinik Nordrhein mit Abteilung Rhein-Ruhr.
Z Kardiol. 1994 Sep;83(9):646-51.
The long-term antihypertensive efficacy of molsidomine 8 mg bid was studied in 24 patients with coronary artery disease in a double-blind, placebo-controlled trial of 3 weeks duration. Ambulatory 24-h blood pressure measurements were performed at days 1, 2, 7, 14, and 21. Sphygmomanometric measurements of blood pressure heart rate and a protocol for number and time of angina pectoris attacks were also taken. Following the application of molsidomine a reduction of mean 24-h systolic blood pressure of 14% and of mean diastolic blood pressure of 11% was observed. The duration of the blood-pressure-lowering action was 7 h. After 3 weeks of treatment with 8 mg molsidomine sr bid a persistent and significant reduction of systolic and diastolic blood pressure was found. A similar acute and long-term effect was found by manually measured blood pressures. Heart rate was unchanged under molsidomine while the frequency of angina pectoris was diminished. In conclusion, a long-lasting antihypertensive efficacy (without signs of tolerance) was found over a 3-week period of treatment with 8 mg molsidomine in a slow-release formulation given twice a day.
在一项为期3周的双盲、安慰剂对照试验中，对24例冠心病患者研究了8毫克莫索尼定每日两次的长期降压疗效。在第1、2、7、14和21天进行24小时动态血压测量。还进行了血压、心率的血压计测量以及心绞痛发作次数和时间的记录。应用莫索尼定后，观察到平均24小时收缩压降低14%，平均舒张压降低11%。降压作用持续时间为7小时。在用8毫克缓释莫索尼定每日两次治疗3周后，发现收缩压和舒张压持续且显著降低。通过手动测量血压也发现了类似的急性和长期效果。在莫索尼定治疗期间心率未变，而心绞痛频率降低。总之，在一项为期3周的治疗中，每日两次给予8毫克缓释莫索尼定可产生持久的降压疗效（无耐受性迹象）。
