三种药物可抑制磷脂酶A2诱导的内皮细胞单层高通透性。
Three drugs inhibit phospholipase A2-induced high permeability of endothelial monolayers.
作者信息
Chen S F, Li S H, Ding F Y
机构信息
Department of Pathophysiology, Second Military Medical University, Shanghai, China.
出版信息
Zhongguo Yao Li Xue Bao. 1994 Jul;15(4):299-302.
The permeability of aortic endothelial monolayers to fluid and albumin increased 13.5 and 16.1 times respectively after pretreatment with phospholipase A2 (PLA2, 100 U.ml-1) for 30 min. 1-(p-Chlorobenzoyl)-5-methylindole-3-acetic acid (1.16 mmol.L-1), SRI 63-441 (30 nmol.L-1), and 1,25-dihydroxycholecalciferol (0.1 mumol.L-1) decreased PLA2-induced high permeability. PLA2 did not damage the endothelial cells significantly. Our results indicate that the action of PLA2 to increase the permeability of endothelial monolayers is mainly due to PLA2-induced lipid mediators released from endothelial cells.
用磷脂酶A2（PLA2，100 U.ml-1）预处理30分钟后，主动脉内皮单层对液体和白蛋白的通透性分别增加了13.5倍和16.1倍。1-（对氯苯甲酰基）-5-甲基吲哚-3-乙酸（1.16 mmol.L-1）、SRI 63-441（30 nmol.L-1）和1,25-二羟基胆钙化醇（0.1 mumol.L-1）可降低PLA2诱导的高通透性。PLA2对内皮细胞没有明显损伤。我们的结果表明，PLA2增加内皮单层通透性的作用主要是由于PLA2诱导内皮细胞释放脂质介质。
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