Yuan B X, Ren H M, Yang G D, Yang Y J, Qi L
Department of Pharmacology, Faculty of Pharmacy, Xi-an Medical University, China.
Zhongguo Yao Li Xue Bao. 1994 Jul;15(4):331-5.
In order to study the location and function of nicotine-sensitive neurons of cardiac ganglial plexuses, microdissections of collections of fat pads were carried out, and nicotine (100 micrograms) was injected into the ganglial plexus between aorta and pulmonary artery (A-PGP) in 30 anesthetized open-chest dogs. There were numerous ganglia or neurons in A-PGP. Either positive or negative inotropic and chronotropic responses were elicited following injections of nicotine into A-PGP. Control injections of 0.1 ml saline into A-PGP and injections of nicotine (100 or 200 micrograms) into right marginal ganglial plexus did not elicit any cardiac responses. After acute decentralization, nicotine (100 micrograms) was again injected into the same locus of A-PGP. Some positive and negative responses could still be induced, but their frequencies were reduced. These suggest that nicotine can directly activate the efferent parasympathetic and sympathetic neurons and indirectly activate them by stimulating the afferent neurons existing on the surface of dog heart.
为研究心脏神经节丛中对尼古丁敏感的神经元的位置和功能，对脂肪垫集合进行了显微解剖，并将尼古丁（100微克）注入30只麻醉开胸犬的主动脉与肺动脉之间的神经节丛（A-PGP）。A-PGP中有大量神经节或神经元。向A-PGP注射尼古丁后，可引发正向或负向的变力性和变时性反应。向A-PGP注射0.1毫升生理盐水以及向右侧边缘神经节丛注射尼古丁（100或200微克）均未引发任何心脏反应。急性去神经支配后，再次将尼古丁（100微克）注入A-PGP的同一部位。仍可诱导出一些正向和负向反应，但频率降低。这些结果表明，尼古丁可直接激活传出性副交感和交感神经元，并通过刺激犬心脏表面存在的传入神经元间接激活它们。
