Newman P J, Quinn A C, Hall G M, Grounds R M
Department of Anaesthesia, St George's Hospital Medical School, London.
Anaesthesia. 1994 Nov;49(11):936-9. doi: 10.1111/j.1365-2044.1994.tb04307.x.
Sevoflurane, a new volatile inhalational agent, undergoes biotransformation to fluoride which is potentially nephrotoxic. We compared the effects of sevoflurane or isoflurane anaesthesia on hepatorenal function and serum fluoride concentrations in 50 ASA 1-3 patients undergoing major intra-abdominal surgery. No patient developed renal or hepatic dysfunction. Mean (SEM) peak fluoride concentrations were 23.1 (1.5) mumol.l-1 for sevoflurane and 5.4 (0.4) mumol.l-1 for isoflurane (p < 0.001). There was a significant correlation in the sevoflurane group between the total dose of agent (MAC h), the total fluoride production (r = 0.78, p = 0.0001) and peak fluoride concentration (r = 0.57, p = 0.003). There was no correlation between these variables in the isoflurane group.
七氟烷是一种新型挥发性吸入麻醉剂，可生物转化为具有潜在肾毒性的氟化物。我们比较了七氟烷或异氟烷麻醉对50例接受腹部大手术的美国麻醉医师协会（ASA）1-3级患者肝肾功能及血清氟浓度的影响。所有患者均未出现肝肾功能障碍。七氟烷组的平均（标准误）氟峰值浓度为23.1（1.5）μmol·L-1，异氟烷组为5.4（0.4）μmol·L-1（p<0.001）。在七氟烷组中，麻醉剂总剂量（MAC小时）、总氟生成量（r=0.78，p=0.0001）与氟峰值浓度（r=0.57，p=0.003）之间存在显著相关性。在异氟烷组中，这些变量之间无相关性。
