Sato H, Hoshi M, Sugiyama K, Urushiyama M, Ishizuka K
Institute of Aging, Development and Cancer, Tohoku University.
Gan To Kagaku Ryoho. 1994 Dec;21 Suppl 4:459-61.
Angiotensin II induced hypertension chemotherapy (IHC) is a drug delivery system in which the functional difference of microcirculation between tumor and normal tissue was applied. IHC records of the patients with advanced gastrointestinal cancer, admitted in our hospitals were analysed according to the patterns of the maintenance level and range of blood pressure. Those who were possible to get ambulatory life had significantly good response and long survival in addition to better performance status before IHC, comparing with those who had continued admission life. An optimal range of elevation level and stable maintenance of hypertension induced by the infusion of angiotensin II was essentially required to obtain a good response.
血管紧张素 II 诱导性高血压化疗（IHC）是一种药物递送系统，其利用了肿瘤组织与正常组织之间微循环的功能差异。对我院收治的晚期胃肠道癌患者的 IHC 记录，根据血压维持水平和范围模式进行了分析。与持续住院治疗的患者相比，那些有可能过上非卧床生活的患者在 IHC 之前除了具有更好的体能状态外，还具有显著良好的反应和更长的生存期。为了获得良好的反应，基本上需要由血管紧张素 II 输注诱导的高血压有一个最佳的升高水平范围和稳定维持。
