人类儿茶酚胺硫酸化酚硫酸转移酶基因（STM）的基因组结构与DNA序列

Genomic organization and DNA sequence of the human catecholamine-sulfating phenol sulfotransferase gene (STM).

作者信息

Dooley T P, Probst P, Munroe P B, Mole S E, Liu Z, Doggett N A

机构信息

Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228.

出版信息

Biochem Biophys Res Commun. 1994 Dec 15;205(2):1325-32. doi: 10.1006/bbrc.1994.2810.

DOI:10.1006/bbrc.1994.2810

PMID:7802665

Abstract

The human monoamine neurotransmitter-preferring phenol sulfotransferase (M-PST) plays an essential role in the sulfation of catecholamines, such as dopamine. The cDNA encoding M-PST has been reported, and we have recently identified cosmid clones from human chromosome 16p11.2 for this gene, STM. Plasmid subclones derived from the STM cosmid clones were subjected to dideoxynucleotide chain termination sequencing to determine the genomic organization and DNA sequence of STM. The gene encoding full-length STM is approximately 6.4 kb and contains 8 exons and 7 introns.

摘要

人类单胺类神经递质偏好性酚磺基转移酶（M-PST）在儿茶酚胺（如多巴胺）的硫酸化过程中起重要作用。编码M-PST的cDNA已有报道，我们最近从人类16号染色体p11.2上鉴定出了该基因STM的黏粒克隆。对源自STM黏粒克隆的质粒亚克隆进行双脱氧核苷酸链终止测序，以确定STM的基因组结构和DNA序列。编码全长STM的基因约为6.4 kb，包含8个外显子和7个内含子。