Andrassy K, Eschenfelder V, Koderisch J, Weber E
Department of Medicine, University Hospital, Heidelberg, Germany.
Thromb Res. 1994 Jan 15;73(2):95-108. doi: 10.1016/0049-3848(94)90084-1.
The antithrombotic activity and pharmacokinetics of Clivarin, a low molecular weight heparin was randomly studied in 10 healthy male volunteers. Doses of 20, 40, 60 and 80 anti F Xa U/kg BW were injected intravenously and subcutaneously in crossover fashion. The heparin concentrations were measured by inhibition of clotting assays (anti IIa and anti Xa activities using amidolytic assays and [dilute] thrombin time). The pharmacokinetic profile of Clivarin is characterized by a linear relationship between dose and absorption, relatively low clearance and a long elimination half-life, and a high anti Xa/anti IIa ratio of 5.3.
对一种低分子量肝素——克利肝素的抗血栓活性和药代动力学进行了随机研究，研究对象为10名健康男性志愿者。以交叉方式静脉注射和皮下注射20、40、60和80抗FXa U/kg体重的剂量。通过抑制凝血试验（使用酰胺分解试验和[稀释]凝血酶时间测定抗IIa和抗Xa活性）来测量肝素浓度。克利肝素的药代动力学特征为剂量与吸收之间呈线性关系、清除率相对较低、消除半衰期较长，且抗Xa/抗IIa比率高达5.3。
