Wang E C, Geyer J R, Berger M S
Department of Neurological Surgery, Children's Hospital and Medical Center, University of Washington School of Medicine, Seattle.
Pediatr Neurosurg. 1994;21(3):165-72; discussion 172-3. doi: 10.1159/000120829.
Thirty-one children who underwent 36 subfrontal craniotomies were retrospectively studied to determine the incidence of postoperative epilepsy and the effectiveness of antiepileptic drugs for seizure prophylaxis. The incidence of postoperative epilepsy following a subfrontal craniotomy did not exceed 12% when examined at various time periods during a 3-year postoperative course. Antiepileptic drugs were not warranted to reduce the incidence of postoperative seizures after the 1-month postoperative period and should not be used for long-term prophylactic therapy in children following a subfrontal craniotomy.
对31例接受36次额下开颅手术的儿童进行回顾性研究，以确定术后癫痫的发生率及抗癫痫药物预防癫痫发作的有效性。在术后3年的不同时间段进行检查时，额下开颅术后癫痫的发生率不超过12%。术后1个月后，无需使用抗癫痫药物来降低术后癫痫发作的发生率，且额下开颅术后的儿童不应使用抗癫痫药物进行长期预防性治疗。
