Katz M, Pimstone B L, Carr P J, Hendricks S
J Clin Endocrinol Metab. 1976 Jul;43(1):215-21. doi: 10.1210/jcem-43-1-215.
Intranasal administration of gonadotropin hormone (GnRH) in doses ranging from 2-4 mg produced a consistently prolonged LH response in patients with secondary amenorrhea. In 4 cases, a delayed secondary rise occurred. A similarly prolonged FSH response was observed in the majority of patients. Six hours after intranasal GnRH, FSH and LH values were well above basal levels and were higher than those observed at a similar interval after intravenous GnRH. Plasma GnRH levels after intranasal administration failed to achieve the high peaks found after the intravenous route but maintained elevated levels for at least an hour and often longer. Despite the much lower plasma GnRH levels, intranasal GnRH produced a sustained effect on LH and FSH secretion, greater than GnRH given by the intravenous route.
对继发性闭经患者经鼻给予2 - 4毫克剂量的促性腺激素释放激素（GnRH），可使促黄体生成素（LH）反应持续延长。在4例患者中出现了延迟的第二次升高。大多数患者观察到类似的促卵泡生成素（FSH）反应延长。经鼻给予GnRH 6小时后，FSH和LH值远高于基础水平，且高于静脉注射GnRH后相同时间间隔所观察到的值。经鼻给药后血浆GnRH水平未能达到静脉给药后出现的高峰，但至少维持升高水平1小时，且常常更长。尽管血浆GnRH水平低得多，但经鼻给予GnRH对LH和FSH分泌产生的持续作用大于静脉途径给予的GnRH。
