Cavaletti G, Tredici G, Marmiroli P, Fabbrica D, Braga M
Institute of Human Anatomy, University of Milan, Italy.
In Vivo. 1994 May-Jun;8(3):313-6.
As yet little is known about the off-treatment course of cisplatin (CDDP) neurotoxicity. In this study we evaluated in the rat how the pathological changes in dorsal root ganglia (DRG) neurons and the electrophysiological alterations in peripheral nerves induced by chronic CDDP administration evolved after drug withdrawal. Twelve female Wistar rats were treated with CDDP and 3 of them were sacrificed 1, 5, 10 and 20 weeks after treatment. The results of the experiment indicated that: 1) the damage induced by sub-lethal doses of CDDP in the DRG neurons is reversible, 2) the first structures to be damaged are the DRG neurons (mostly their nucleoli) and 3) both damage and recovery in the follow-up period involve first the DRG neurons and subsequently the peripheral nerves.
迄今为止，对于顺铂（CDDP）神经毒性的停药后病程仍知之甚少。在本研究中，我们评估了在大鼠中，慢性给予CDDP后，背根神经节（DRG）神经元的病理变化以及外周神经的电生理改变在停药后是如何演变的。12只雌性Wistar大鼠接受了CDDP治疗，其中3只在治疗后1、5、10和20周被处死。实验结果表明：1）亚致死剂量的CDDP对DRG神经元造成的损伤是可逆的，2）首先受损的结构是DRG神经元（主要是它们的核仁），3）在随访期内，损伤和恢复首先涉及DRG神经元，随后是外周神经。
