Chessells J M
Institute of Child Health, London, UK.
Baillieres Clin Haematol. 1994 Jun;7(2):349-63. doi: 10.1016/s0950-3536(05)80207-0.
CNS-directed treatment is an essential component of therapy for both children and adults with acute lymphoblastic leukaemia. The choice between combinations of i.t. drugs, radiotherapy and high-dose systemic chemotherapy is not a clear one and will depend on the age of the patient, the type of leukaemia and indeed the available treatment facilities. A plea is made for any prospective trials of CNS-directed therapy to incorporate formal assessment of neuropsychological performance, and in the young child, of growth and pubertal progression.
