一名患有非活动性系统性红斑狼疮的血液透析患者发生获得性特发性纯红细胞再生障碍。
Acquired idiopathic pure red cell aplasia in a hemodialyzed patient with inactive systemic lupus erythematosus.
作者信息
Okada H, Suzuki H, Uchida H, Kanno Y, Kitamura Y, Hisamatsu T, Deguchi N, Hayashi D, Saruta T
机构信息
Department of Internal Medicine, Keio University School of Medicine, Tokyo.
出版信息
Intern Med. 1994 Aug;33(8):492-5. doi: 10.2169/internalmedicine.33.492.
A male patient suffered chronic renal failure due to lupus nephritis and was undergoing hemodialysis. Six years after beginning hemodialysis, anemia developed, which improved by erythropoietin. Unresponsiveness to erythropoietin gradually appeared, and with a suspicion of pure red cell aplasia, he was treated with a high-dose corticosteroid but the unresponsiveness did not improve. Neither his serum nor lymphocytes inhibited erythropoiesis of either normal bone marrow stem cells or his own in vitro. These observations suggest an impaired hematopoietic microenvironment in his bone marrow.
一名男性患者因狼疮性肾炎患有慢性肾衰竭，正在接受血液透析。开始血液透析六年后，出现贫血，使用促红细胞生成素后贫血有所改善。逐渐出现对促红细胞生成素无反应的情况，怀疑为纯红细胞再生障碍性贫血，遂用大剂量皮质类固醇进行治疗，但无反应情况并未改善。其血清和淋巴细胞在体外均未抑制正常骨髓干细胞或其自身的红细胞生成。这些观察结果提示其骨髓造血微环境受损。
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