Blackwell C C, Weir D M, Busuttil A, Saadi A T, Essery S D, Raza M W, James V S, Mackenzie D A
Department of Medical Microbiology, Medical School, University of Edinburgh, UK.
FEMS Immunol Med Microbiol. 1994 Aug;9(2):91-100. doi: 10.1111/j.1574-695X.1994.tb00479.x.
Epidemiological factors associated with susceptibility to respiratory infections are similar to those associated with Sudden Infant Death Syndrome. Here we review the evidence that respiratory pathogens might be involved in some cases of Sudden Infant Death Syndrome in the context of factors identified in epidemiological studies of cot deaths: the age range affected; mother' smoking; respiratory viral infections; immunisation status. Both laboratory and epidemiological evidence suggests that vulnerability of infants to infectious agents depends on interactions between genetic, developmental and environmental factors that contribute to colonisation by microorganisms, the inflammatory and specific immune responses and the infants' physiological responses to inflammatory mediators. A model is proposed to explain how microorganisms might trigger a series of events resulting in some of these unexpected deaths and discusses how the the present recommendations regarding child care practices might help reduce the numbers of Sudden Infant Death Syndrome cases associated with infectious agents.
与呼吸道感染易感性相关的流行病学因素与婴儿猝死综合征相关因素相似。在此，我们结合婴儿床死亡流行病学研究中确定的因素，即受影响的年龄范围、母亲吸烟、呼吸道病毒感染、免疫状况，回顾呼吸道病原体可能与某些婴儿猝死综合征病例有关的证据。实验室和流行病学证据均表明，婴儿对传染原的易感性取决于遗传、发育和环境因素之间的相互作用，这些因素导致微生物定植、炎症和特异性免疫反应以及婴儿对炎症介质的生理反应。本文提出了一个模型，以解释微生物如何引发一系列事件，导致这些意外死亡，并讨论了目前关于儿童护理实践的建议如何有助于减少与传染原相关的婴儿猝死综合征病例数量。
