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Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide.

作者信息

Gazzinelli R T, Hayashi S, Wysocka M, Carrera L, Kuhn R, Muller W, Roberge F, Trinchieri G, Sher A

机构信息

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892.

出版信息

J Eukaryot Microbiol. 1994 Sep-Oct;41(5):9S.

PMID:7804285
Abstract
摘要

相似文献

1
Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide.
J Eukaryot Microbiol. 1994 Sep-Oct;41(5):9S.
2
Toxoplasma gondii: evidence for interleukin-12-dependent and-independent pathways of interferon-gamma production induced by an attenuated parasite strain.刚地弓形虫：减毒寄生虫株诱导γ干扰素产生的白细胞介素-12依赖和非依赖途径的证据
Exp Parasitol. 1996 Nov;84(2):102-14. doi: 10.1006/expr.1996.0096.
3
Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-alpha and nitric oxide from macrophages via IFN-gamma induction.白细胞介素-12在细胞内感染期间巨噬细胞激活中的作用：白细胞介素-12与分枝杆菌通过诱导γ干扰素协同从巨噬细胞释放肿瘤坏死因子-α和一氧化氮。
J Leukoc Biol. 2000 Dec;68(6):897-902.
4
IL-10 is not required to prevent immune hyperactivity during memory responses to Toxoplasma gondii.在对刚地弓形虫的记忆反应过程中，预防免疫亢进并不需要白细胞介素-10。
Parasite Immunol. 2004 May;26(5):229-36. doi: 10.1111/j.0141-9838.2004.00704.x.
5
Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- mice.一氧化氮（NO）的产生对于IRF-1基因敲除小鼠抵御急性弓形虫感染并非必不可少。
J Immunol. 1996 Jan 15;156(2):636-43.
6
Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection.细胞介导免疫的缺陷影响小鼠对鸟分枝杆菌感染的慢性抵抗力，但不影响先天抵抗力。
J Immunol. 1997 May 15;158(10):4822-31.
7
Immunity induced by DNA vaccine of plasmid encoding the rhoptry protein 1 gene combined with the genetic adjuvant of pcIFN-gamma against Toxoplasma gondii in mice.编码棒状体蛋白1基因的质粒DNA疫苗与pcIFN-γ基因佐剂联合诱导小鼠抗弓形虫免疫
Chin Med J (Engl). 2001 Mar;114(3):317-20.
8
Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha.刚地弓形虫在自然杀伤细胞中诱导非T细胞依赖的γ干扰素反应，这需要黏附辅助细胞和肿瘤坏死因子-α。
J Immunol. 1993 May 1;150(9):3982-9.
9
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.寄生虫诱导的白细胞介素-12在急性弓形虫感染期间刺激早期γ干扰素的合成并增强抵抗力。
J Immunol. 1994 Sep 15;153(6):2533-43.
10
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.在缺乏内源性干扰素-γ的情况下，小鼠对刚地弓形虫产生的白细胞介素-12反应未受损害，但无法控制急性感染。
J Immunol. 1996 Nov 1;157(9):4045-54.

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Pteridines. 2019 Feb;30(1):1-9. doi: 10.1515/pteridines-2019-0001. Epub 2019 Feb 19.
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The immunomodulatory effects of rolipram abolish drug-resistant latent phase of infection in a murine model.咯利普兰的免疫调节作用消除了小鼠模型中耐药性感染的潜伏期。
J Microsc Ultrastruct. 2015 Apr-Jun;3(2):86-91. doi: 10.1016/j.jmau.2014.12.001. Epub 2015 Jan 7.
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MIF Promotes Classical Activation and Conversion of Inflammatory Ly6C(high) Monocytes into TipDCs during Murine Toxoplasmosis.在小鼠弓形虫病期间，巨噬细胞移动抑制因子促进炎症性Ly6C（高）单核细胞的经典活化并将其转化为TipDCs。
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