Croteau S, Menezo Y
Laboratoire de biologie appliquée, INSA-Bât. 406, Villeurbanne.
Contracept Fertil Sex. 1994 Oct;22(10):648-55.
Developmental arrests and losses of viability are observed in vitro, when embryos are cultured. A harmonious oocyte maturation is essential to obtain a balanced development. Factors that control this maturation are still unknown but growth factors seem to be involved: they are present in ovary and some of them (EGF, TGF-alpha, TGF-beta, PDGF) improve in vitro maturation. These factors are also involved in preimplantation development, either in an autocrine way (ligand and receptor genes expression in the embryo) or in a paracrine way (receptor gene expression in the embryo and ligand gene expression in the tractus). However, the precise role of each one and their interrelations are still speculative.
当胚胎在体外培养时，会观察到发育停滞和活力丧失的情况。和谐的卵母细胞成熟对于实现平衡发育至关重要。控制这种成熟的因素仍然未知，但生长因子似乎与之相关：它们存在于卵巢中，其中一些（表皮生长因子、转化生长因子-α、转化生长因子-β、血小板衍生生长因子）可改善体外成熟。这些因子也参与植入前发育，或以自分泌方式（胚胎中配体和受体基因表达），或以旁分泌方式（胚胎中受体基因表达和生殖道中配体基因表达）。然而，每种因子的确切作用及其相互关系仍属推测。
