Osumi A K, Mclendon R E, Tien R D, Friedman H S, Graham M, Hockenberger B, Halperin E C, Oakes W J
Department of Radiology, Duke University Medical Center, Durham, NC 27710.
Clin Neuropathol. 1994 Sep-Oct;13(5):281-5.
Conventional treatment for medulloblastoma includes surgical resection followed by craniospinal irradiation, with the potential risk of subsequent radiotherapy-induced secondary neoplasms. We report a 23-year-old woman previously irradiated nine years earlier for a cerebellar medulloblastoma who developed a new enhancing lesion in the primary radiation field four weeks following completion of high dose chemotherapy with bone marrow transplantation for recurrent disease. Resection of this lesion revealed a low grade glioma with no evidence of recurrent medulloblastoma.
髓母细胞瘤的传统治疗方法包括手术切除，随后进行全脑全脊髓放疗，存在后续放疗诱发继发性肿瘤的潜在风险。我们报告了一名23岁女性，9年前因小脑髓母细胞瘤接受过放疗，在因复发性疾病完成高剂量化疗及骨髓移植四周后，在原放疗区域出现了一个新的强化病灶。切除该病灶后发现是一个低级别胶质瘤，没有髓母细胞瘤复发的迹象。
