Liao C X, Li J S
Department of General Surgery, Nanfang Hospital, Guangzhou.
Chin Med J (Engl). 1994 Sep;107(9):669-72.
The aim of this study was to evaluate whether Tripterygium wilfordii (TW) could be used as an immunosuppressant, and whether antirejection therapy with low-dose cyclosporin A (CsA) and TW was better than the treatment with large-dose CsA alone in intestinal transplantation in pigs. 100 cm intestines were transplanted by using two-step models. Four pigs which received large-dose CsA for 100 days and then were given TW survived 251.5 +/- 181.5 days; 2 of these died of pneumonia 92 and 97 days after the operations respectively. Five pigs which received low-dose CsA and TW for 100 days, then TW was the only drug used in the survival animals, survived 243.2 +/- 90.9 days; none of these succumbed to infection. All the grafts in those which were administered with low-dose CsA were destroyed by acute rejection at 12.4 +/- 2.6 days. These results indicated that TW had some immunosuppressive effects, and antirejection treatment with low-dose CsA and TW could be considered as an acceptable therapy in small bowel transplantation.
本研究的目的是评估雷公藤（TW）是否可用作免疫抑制剂，以及在猪小肠移植中，低剂量环孢素A（CsA）与TW联合抗排斥治疗是否优于单独使用大剂量CsA治疗。采用两步法模型移植100厘米长的肠段。4只猪接受大剂量CsA治疗100天，然后给予TW，存活了251.5±181.5天；其中2只分别在术后92天和97天死于肺炎。5只猪接受低剂量CsA和TW治疗100天，然后存活的动物仅使用TW，存活了243.2±90.9天；这些猪均未死于感染。所有接受低剂量CsA治疗的猪的移植物在12.4±2.6天被急性排斥反应破坏。这些结果表明，TW具有一定的免疫抑制作用，低剂量CsA与TW联合抗排斥治疗可被视为小肠移植中一种可接受的治疗方法。
