Zhou Z S
Department of Pathology and General Surgery, Jinling Hospital, Nanjing.
Zhonghua Yi Xue Za Zhi. 1993 Sep;73(9):541-3, 575.
Segmental small bowel allografts in pigs were examined histologically to elucidate the rejection process. The specimens were obtained by biopsy at regular intervals after transplantation. Early characteristics of acute rejection were marked by infiltration of mononuclear cells in the lamina propria. Moderate rejection showed increased infiltrated mononuclear cells and mucosal lesions. Mucosal necrosis occurred in the acute phase of rejection. Rejection was seen in the animals that received only low-dose cyclosporin A but not in those treated with tripterygium wilfordii (TW) and low-dose cyclosporin A. These results suggest that mucosal biopsy as a way of monitoring rejection can show sequential pattern of changes. Normal morphological appearance of TW-treated allografts confirmed that TW is an effective immunosuppressant.
对猪的节段性小肠异体移植进行组织学检查以阐明排斥反应过程。移植后定期通过活检获取标本。急性排斥反应的早期特征是固有层单核细胞浸润。中度排斥反应表现为浸润的单核细胞增多和黏膜病变。黏膜坏死发生在排斥反应的急性期。仅接受低剂量环孢素A的动物出现了排斥反应，而接受雷公藤（TW）和低剂量环孢素A治疗的动物则未出现排斥反应。这些结果表明，黏膜活检作为监测排斥反应的一种方法可以显示出连续的变化模式。TW治疗的异体移植的正常形态外观证实TW是一种有效的免疫抑制剂。
