Li L Y, Luo W C, Lu Z L
Peking Union Medical College Hospital, Beijing.
Zhonghua Zhong Liu Za Zhi. 1994 Jul;16(4):291-4.
Serum N-POMC level of 103 cases of lung cancer were measured in our hospital. The results were as follows: The lung cancer group, 50.5%, of patienst has an N-PONC level above the normal upper limit. The percentages of the N-POMC levels above the normal limit in lung cancers, such as: squamous-cell carcinoma, adenocarcinoma, SCLC and undifferentiated carcinoma were 52.2%, 50.0%, 47.3% and 57.1%, respectively. There was no statistically significant difference of N-POMC levels among these kinds of lung cancers, Eleven of 18 cases of SCLC patients in stage IIIb or IV, and 3 of 9 cases of SCLC patients in stage IIIa had N-POMC levels above the upper normal limit. Could serum N-POMC be one of the indexes for assisting the diagnosis and prognosis of lung cancer needs further investigation. Cases with carcinoid, thymoma and neurofibroma had higher N-POMC levels too. Six patients had Cushing syndrome.
我院检测了103例肺癌患者的血清N-POMC水平。结果如下：肺癌组中，50.5%的患者N-PONC水平高于正常上限。在鳞状细胞癌、腺癌、小细胞肺癌和未分化癌等肺癌类型中，N-POMC水平高于正常上限的百分比分别为52.2%、50.0%、47.3%和57.1%。这些类型的肺癌之间N-POMC水平无统计学显著差异。18例Ⅲb期或Ⅳ期小细胞肺癌患者中有11例，9例Ⅲa期小细胞肺癌患者中有3例N-POMC水平高于正常上限。血清N-POMC能否作为辅助肺癌诊断和预后的指标之一尚需进一步研究。类癌、胸腺瘤和神经纤维瘤患者的N-POMC水平也较高。6例患者患有库欣综合征。
