促甲状腺激素释放激素（TRH）对大鼠边缘叶癫痫持续状态的影响。

The effect of thyrotropin-releasing hormone (TRH) on limbic status epilepticus in rats.

作者信息

Osonoe K, Osonoe M, Ariga K, Mori N

机构信息

Department of Neuropsychiatry, Fukushima Medical College, Japan.

出版信息

Epilepsy Res. 1994 Jul;18(3):217-25. doi: 10.1016/0920-1211(94)90042-6.

DOI:10.1016/0920-1211(94)90042-6

PMID:7805643

Abstract

We produced limbic status epilepticus in rats by injecting a combination of dibutyryl-cAMP (db-cAMP) and ethylenediaminetetraacetic acid (EDTA) into the amygdala (AM). Thirty minutes after intra-AM db-cAMP/EDTA injection, thyrotropin-releasing hormone (TRH) was administered intravenously or intracerebroventricularly. Intravenous TRH (3, 25, 50 mg/kg) produced immediate activation of electroclinical seizures, lasting for 25-45 min. In some animals which showed this seizure activation, complete seizure suppression occurred 55-70 min after the TRH treatment. Similar activation of ictal seizures with delayed seizure suppression was obtained after intracerebroventricular TRH (25, 50 micrograms). The findings suggest that the effects of intravenous TRH are due to its central action and that the use of intravenous TRH is not a promising approach for the treatment of status epilepticus.

摘要

我们通过向大鼠杏仁核（AM）注射二丁酰环磷腺苷（db-cAMP）和乙二胺四乙酸（EDTA）的组合来诱导边缘性癫痫持续状态。在杏仁核内注射db-cAMP/EDTA 30分钟后，静脉内或脑室内给予促甲状腺激素释放激素（TRH）。静脉注射TRH（3、25、50mg/kg）可立即激活电临床癫痫发作，持续25至45分钟。在一些出现这种癫痫发作激活的动物中，TRH治疗后55至70分钟癫痫发作完全被抑制。脑室内注射TRH（25、50微克）后也获得了类似的发作期癫痫激活及延迟的癫痫发作抑制。这些发现表明静脉注射TRH的作用是由于其中枢作用，并且静脉注射TRH并非治疗癫痫持续状态的有效方法。