Piemontino U, Ceriello A, Di Minno G
Clinica Medica, Università degli Studi di Napoli, Italy.
Haematologica. 1994 Jul-Aug;79(4):387-92.
As many as 80% of diabetic patients die from major thrombotic complications of atherosclerosis, stroke and myocardial infarction. Plasma and cellular components of the hemostatic system are often abnormal in diabetic patients, and some of these abnormalities may play a role in the high risk of thrombosis in these patients.
Clinical studies imply that certain hemostatic abnormalities of diabetic patients are related, to some extent, to poor metabolic control. Thus, a critical review of the data available in the specialized literature has been carried out.
Although suggestive, the link between hemostatic and metabolic abnormalities in diabetes mellitus is only circumstantial. Little is known about similarities and differences between type I and type II diabetes mellitus with respect to hemostatic parameters. Likewise, current understanding of the effects on the hemostatic system of the combination of glucose and lipid abnormalities often coexisting in diabetic patients is rather limited.
Ad hoc studies are mandatory to clarify unsolved issues in this field and define the extent to which good metabolic control is crucial to preventing the risk of thrombosis in diabetes mellitus.
多达80%的糖尿病患者死于动脉粥样硬化、中风和心肌梗死等主要血栓并发症。止血系统的血浆和细胞成分在糖尿病患者中常常异常，其中一些异常可能在这些患者的高血栓形成风险中起作用。
临床研究表明，糖尿病患者的某些止血异常在一定程度上与代谢控制不佳有关。因此，对专业文献中的现有数据进行了批判性综述。
尽管有提示作用，但糖尿病患者止血和代谢异常之间的联系只是间接的。关于I型和II型糖尿病在止血参数方面的异同知之甚少。同样，目前对于糖尿病患者中常常并存的葡萄糖和脂质异常组合对止血系统的影响的理解相当有限。
必须进行专门研究以澄清该领域未解决的问题，并确定良好的代谢控制对预防糖尿病患者血栓形成风险的关键程度。
