Ar'Rajab A, Dawidson I J, Harris R B, Sentementes J T
Department of Surgery, University of Texas Southwestern Medical Center, Dallas.
Horm Metab Res. 1994 Aug;26(8):355-9. doi: 10.1055/s-2007-1001705.
This study tested the hypothesis that normalization of glucose homeostasis after islet transplantation is correlated to the number of islets, and by increasing this number a complete normalization of glucose homeostasis could be achieved, 1,200 or 2,400 islets were transplanted into the left kidney subcapsular space in streptozotocin-induced diabetic rats. Intravenous glucose tolerance tests were performed at 10 days, 3 and 6 months after transplantation. Transplantation of both 1,200 and 2,400 islets normalized the basal blood glucose levels within 24-48 hours, which remained normal for the entire study period of 6 months. Basal plasma insulin levels and body weight were also normalized in both transplanted groups. Transplantation of 2,400 islets achieved normal glucose-induced insulin secretion at 10 days after transplantation and for the following 6 months. In contrast, glucose intolerance was present in rats transplanted with only 1,200 islets. It is concluded that complete glucose homeostasis after islet transplantation is dependent on the number of transplanted islets and can be achieved by increasing this number.
胰岛移植后葡萄糖稳态的正常化与胰岛数量相关，并且通过增加胰岛数量可实现葡萄糖稳态的完全正常化。将1200个或2400个胰岛移植到链脲佐菌素诱导的糖尿病大鼠的左肾被膜下间隙。在移植后10天、3个月和6个月进行静脉葡萄糖耐量试验。移植1200个和2400个胰岛均在24 - 48小时内使基础血糖水平正常化，在整个6个月的研究期间血糖水平一直保持正常。两个移植组的基础血浆胰岛素水平和体重也恢复正常。移植2400个胰岛在移植后10天及随后6个月实现了正常的葡萄糖诱导的胰岛素分泌。相比之下，仅移植1200个胰岛的大鼠存在葡萄糖不耐受。得出的结论是，胰岛移植后完全的葡萄糖稳态依赖于移植的胰岛数量，并且通过增加该数量可以实现。
