Lau A H, Kronfol N O
Department of Pharmacy Practice, University of Illinois at Chicago.
Int J Artif Organs. 1994 Jul;17(7):373-8.
Continuous hemofiltration was conducted in vitro to identify parameters that affect drug transport across hemofilter membranes. The removal of seven drugs with different molecular weights and protein binding characteristics was assessed. Sieving coefficients were determined with both blood and saline using polysulfone, polyacrylonitrile and polyamide membranes. Drug sieving coefficients obtained with saline were generally higher than those obtained with blood. Molecular weights of the drugs did not correlate with the magnitude of drug sieving. Sieving coefficients in blood were also predicted from saline data assuming plasma protein binding is responsible for the reduced drug sieving with blood. For drugs that are highly protein bound, protein binding was the primary factor limiting drug sieving. Presence of plasma proteins also had a modest effect on sieving of other drugs. The sieving coefficients obtained with the polyacrylonitrile membrane tend to be different from those obtained with the other hemofilters. Drug-membrane interaction may contribute to the differences in drug transport among the membranes.
在体外进行连续血液滤过，以确定影响药物跨血液滤过膜转运的参数。评估了七种具有不同分子量和蛋白结合特性的药物的清除情况。使用聚砜、聚丙烯腈和聚酰胺膜，分别用血液和生理盐水测定筛系数。用生理盐水获得的药物筛系数通常高于用血液获得的筛系数。药物的分子量与药物筛系数的大小无关。假设血浆蛋白结合是导致血液中药物筛系数降低的原因，也可根据生理盐水数据预测血液中的筛系数。对于高蛋白结合药物，蛋白结合是限制药物筛过的主要因素。血浆蛋白的存在对其他药物的筛过也有一定影响。聚丙烯腈膜获得的筛系数往往与其他血液滤过器获得的筛系数不同。药物-膜相互作用可能导致各膜之间药物转运的差异。
