Zhou S L, Pickles J O
Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia.
Hear Res. 1994 Sep;79(1-2):147-60. doi: 10.1016/0378-5955(94)90136-8.
Guinea pigs, aged from 3 weeks before term to 31 weeks after birth, were prepared for scanning electron microscopy. Examination of the extreme apex of the cochlea showed apparently pathological hair cells, even 3 weeks before term. The pathologies included loss and fusion of stereocilia, and the formation of giant stereocilia. The pathologies were most prevalent on row 3 of outer hair cells, declining to outer hair cell rows 2 and 1, with the inner hair cells being least affected. The abnormalities increased with time, increasing rapidly over the first few weeks of life, and more slowly thereafter. It is suggested that early degeneration in the extreme cochlear apex forms a novel model for spontaneous hair cell degeneration, with applicability to other types of spontaneous hair cell degeneration.
选用出生前3周龄至出生后31周龄的豚鼠进行扫描电子显微镜检查。对耳蜗极端顶端的检查显示，甚至在出生前3周就有明显的病理性毛细胞。这些病理变化包括静纤毛的缺失和融合，以及巨型静纤毛的形成。这些病理变化在外毛细胞第3排最为普遍，向外毛细胞第2排和第1排逐渐减少，内毛细胞受影响最小。异常情况随时间增加，在生命的最初几周迅速增加，此后增加较慢。有人提出，耳蜗极端顶端的早期退化形成了一种新的自发性毛细胞退化模型，适用于其他类型的自发性毛细胞退化。
