牛肺表面活性物质疗法与早产儿视网膜病变

Bovine surfactant therapy and retinopathy of prematurity.

作者信息

McGinnity F G, Girschek P K, Morin J D, O'Donoghue E P, Dunn M S

机构信息

Department of Ophthalmology, Hospital for Sick Children, Toronto.

出版信息

J Pediatr Ophthalmol Strabismus. 1994 Jul-Aug;31(4):238-41. doi: 10.3928/0191-3913-19940701-09.

DOI:10.3928/0191-3913-19940701-09

PMID:7807300

Abstract

We reviewed the results of three randomized clinical trials of prophylactic bovine surfactant therapy on babies under 30 weeks gestational age to assess the effects of this treatment on the frequency and severity of retinopathy of prematurity (ROP). Of the 119 babies who received surfactant treatment, 54 (45.4%) had ROP compared to 33 (47.1%) of the 70 babies in the control group. Stage 2 ROP or greater was noted in 10 (8.4%) babies in the treatment group and in 10 (14.3%) of the untreated group. Prophylactic bovine surfactant replacement therapy does not have a significant effect on the frequency of ROP in preterm babies. The severity of ROP also appears to be unaffected by surfactant.

摘要

我们回顾了三项针对孕龄小于30周婴儿的预防性牛肺表面活性剂治疗的随机临床试验结果，以评估该治疗对早产儿视网膜病变（ROP）的发生频率和严重程度的影响。在接受表面活性剂治疗的119名婴儿中，54名（45.4%）发生了ROP，而对照组70名婴儿中有33名（47.1%）发生了ROP。治疗组10名（8.4%）婴儿出现2期或更严重的ROP，未治疗组有10名（14.3%）出现此类情况。预防性牛肺表面活性剂替代疗法对早产儿ROP的发生频率没有显著影响。表面活性剂似乎也不会影响ROP的严重程度。