Rivlin M E, Patel R B, Hess L W, Hess D B, Meeks G R
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson.
J Reprod Med. 1994 Sep;39(9):663-6.
This study measured the changes in uterine volume, uterine vascular resistive index and lumbar vertebral bone density before and after a six-month course of leuprolide acetate depot in women with uterine leiomyomas. All nine patients studied were black. The high baseline bone density of black women may provide a greater scope for the use of gonadotropin agonists as compared to women in the general population. A significant reduction in uterine volume was achieved in the patients with leuprolide therapy. Uterine vascular resistive indices were not altered consistently following leuprolide therapy in women with leiomyomas.
本研究测量了患有子宫肌瘤的女性在接受六个月醋酸亮丙瑞林缓释剂治疗前后子宫体积、子宫血管阻力指数和腰椎骨密度的变化。所研究的全部九名患者均为黑人。与一般人群中的女性相比，黑人女性较高的基线骨密度可能为使用促性腺激素激动剂提供更大的空间。接受亮丙瑞林治疗的患者子宫体积显著减小。子宫肌瘤女性接受亮丙瑞林治疗后，子宫血管阻力指数并未持续改变。
