Hansson L
Department of Geriatrics, University of Uppsala, Sweden.
J Hum Hypertens. 1994 Sep;8 Suppl 1:S31-4.
When treating cardiovascular disorders such as arterial hypertension, the major goal of treatment is to reduce morbidity and mortality. The present review will concentrate on how the treatment of cardiovascular disorders affects mortality. Hypertension studies performed in the 1950s showed that treatment of malignant hypertension improved five year survival dramatically. More recent studies in patients with nonmalignant hypertension have shown positive effects on mortality as well, especially with regard to the treatment of hypertension in the elderly. Other cardiovascular disorders have also been treated successfully with regard to mortality. This is true in particular of postmyocardial infarction patients, in whom beta-blocker treatment has been effective. Moreover, patients with congestive heart failure have been shown to benefit from treatment with angiotensin converting enzyme (ACE) inhibitors as regards total mortality. The most recent addition to our knowledge stems from the GISSI-3 trials in which lisinopril, alone or in combination with nitrates, was shown to reduce mortality in patients with acute myocardial infarction.
在治疗诸如动脉高血压等心血管疾病时，治疗的主要目标是降低发病率和死亡率。本综述将聚焦于心血管疾病的治疗如何影响死亡率。20世纪50年代进行的高血压研究表明，恶性高血压的治疗显著提高了五年生存率。最近对非恶性高血压患者的研究也显示出对死亡率的积极影响，尤其是在老年高血压治疗方面。其他心血管疾病在死亡率方面也得到了成功治疗。心肌梗死后患者的情况尤其如此，β受体阻滞剂治疗对他们有效。此外，充血性心力衰竭患者在总死亡率方面已被证明受益于血管紧张素转换酶（ACE）抑制剂治疗。我们最新了解到的情况来自GISSI - 3试验，其中显示赖诺普利单独使用或与硝酸盐联合使用可降低急性心肌梗死患者的死亡率。
