Thomas C R, Stelzer K J, Douglas J G, Koh W J, Wood L V, Panicker R
Division of Oncology, University of Washington School of Medicine, Seattle.
J Natl Med Assoc. 1994 Nov;86(11):839-52.
This article completes a summary of the common medical emergencies that can occur as a result of infectious processes (Part I) and antitumor treatment secondary to chemotherapy, biological response modifiers, or radiotherapy (Part II). The use of high-dose cytotoxic agents, coupled with the common instillation of indwelling central venous access devices, have altered the spectrum of infectious etiologies that are appreciated in clinical practice. In addition, a myriad of cytotoxic agents and radiotherapeutic treatment schemes are used widely in clinical oncologic practice. While most of their related side effects are not considered life-threatening emergencies, they can be fatal if not recognized early and treated promptly. Moreover, some of these infectious and treatment-related sequelae can be prevented. This article highlights some of these clinical observations.
本文完成了对因感染过程(第一部分)以及化疗、生物反应调节剂或放疗后的抗肿瘤治疗(第二部分)可能引发的常见医疗紧急情况的总结。高剂量细胞毒性药物的使用,再加上留置中心静脉通路装置的普遍植入,改变了临床实践中所认识到的感染病因谱。此外,多种细胞毒性药物和放射治疗方案在临床肿瘤学实践中被广泛使用。虽然它们的大多数相关副作用不被视为危及生命的紧急情况,但如果不及早识别并及时治疗,可能会致命。而且,其中一些感染及与治疗相关的后遗症是可以预防的。本文重点介绍了其中一些临床观察结果。