阿尔茨海默病中轴突双螺旋丝tau的存在：亚微观定位

Presence of axonal paired helical filament-tau in Alzheimer's disease: submicroscopic localization.

作者信息

Bondareff W, Harrington C R, McDaniel S W, Wischik C M, Roth M

机构信息

Department of Psychiatry, University of Southern California, School of Medicine, Los Angeles.

出版信息

J Neurosci Res. 1994 Aug 15;38(6):664-9. doi: 10.1002/jnr.490380609.

DOI:10.1002/jnr.490380609

PMID:7807582

Abstract

While normal adult tau protein is found typically in axons, paired helical filament (PHF) tau has been shown immunohistochemically to be in the somatodendritic compartment in Alzheimer's disease (AD). The small amount of PHF-tau (8-11%) found in white matter with immunochemical methods is shown here by immunoelectron microscopy to be located in axons. It is localized to straight filament variants of PHFs. The small amount of PHF-tau in white matter, therefore, appears not to result from the contamination of immunochemical preparations but to be an integral constituent of affected axons in AD.

摘要

虽然正常成人tau蛋白通常存在于轴突中，但免疫组织化学研究表明，在阿尔茨海默病（AD）中，成对螺旋丝（PHF）tau存在于树突-体细胞区室。免疫化学方法在白质中检测到少量的PHF-tau（8%-11%），免疫电子显微镜显示这些PHF-tau位于轴突中。它定位于PHF的直丝变体。因此，白质中少量的PHF-tau似乎并非免疫化学制剂污染所致，而是AD中受影响轴突的一个组成部分。